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KMID : 0363220070450121253
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Korean Journal of Dermatology
2007 Volume.45 No. 12 p.1253 ~ p.1257
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Clinical Effects of Shark Cartilage Extracts on Erythematotelangiectatic Rosacea Patients
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Han Tae-Young
Huh Chang-Hun
Kim Myeung-Nam
Kim Beom-Joon
Rho Nark-Kyoung
Kim Soo-Hong
Hong Hyuck-Gi
Choi Yeon-Sik
Jo Young-Chang
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Abstract
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Background: Persistent facial telangiectasia, erythema and flushing are the major cosmetic problems in patients with rosacea. However various therapeutic treatments for rosacea papules and pustules are not effective in reducing telangiectasia and flushing reactions. Matrix-centered theory that dermal matrix degradation can cause telangiectasis, erythema and flushing, is one of the various theories of rosacea pathogenesis. Shark cartilage extracts are collagenase inhibitors and can inhibit dermal matrix degradation.
Objective: The purpose of this study was to evaluate the clinical effects of shark catilage extracts (Venatrix(R)) for erythematotelangiectatic rosacea patients.
Methods: Twenty three patients with erythematotelangiectatic rosacea applied shark cartilage extracts twice daily for up to 8 weeks. Efficacy was evaluated by erythema index using mexameter (MPA 5, CK, Germany) and clinical photography.
Results: Erythema index decreased from 525.7+/-114 to 413.9+/-101.7 (mean reduction: 21.3%) (p<0.1) after 8 weeks treatment. 16 patients (69%) showed excellent or good results by clinical photography. Transient stinging sensation was the most common adverse effect and these symptoms improved after the first few days. There were no other significant side effects.
Conclusion: Shark cartilage extracts may be an effective treatment for mild erythematotelangiectatic rosacea.
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KEYWORD
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Rosacea, Shark cartilage extracts
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